Jacob Scott

Jacob Scott is a radiation oncologist and cancer theoretician who uses primary mathematical methods to develop novel and hopefully translatable biological hypotheses. He came to this position in life by way of a tortuous career path that included astrophysics, nuclear engineering aboard a submarine, teaching physics and coaching wrestling at the high school level – all before beginning his doctorate in medicine. Dr. Scott began his scientific career studying astrophysics at the U.S. Naval Academy, where he graduated with a Bachelor of Science in Physics with merit. He went on to serve in the U.S. Navy’s submarine fleet aboard the U.S.S. Louisiana, where he served as the ship’s reactor controls assistant. After his time in the Navy, Dr. Scott taught advanced placement Physics and coached wrestling at Stanton College preparatory school, which was at the time the #1 public school in the nation. After a short stint at Stanton, he enrolled in medical school at Case Western Reserve University, graduating Alpha Omega Alpha in 2008 and earning his M.D. He then began his specialty training in Radiation Oncology at the Moffitt Cancer Center and Research Institute in Tampa, FL and joined the Integrative Mathematical Oncology research group. He is now enrolled at Oxford University and is reading for a doctor of philosophy in mathematics (DPhil) where he is focusing his theoretical research on the clinical problem that he finds most enigmatic: glioblastoma – a uniformly fatal brain tumor. Jacob’s real passion however, is spending time with his wife, Sarah, and their 3-year-old daughter, Maren, whose imagination and curiosity defy all theory.

Can we stop the imaginectomies? (Jacob Scott)

Science Kit for Jacob Scott



Thank you for your interest in some more background information on my career path and TEDMED talk.  I have had a strange path that has included astrophysics, nuclear engineering, radiation therapy and now mathematical and theoretical cancer biology.  I am attaching a few recent papers that I have written with my colleagues.  One describes the new movement in cancer research that includes physical scientists, whom I have dubbed 'Phase i trialists'.  A second is an example of the sorts of insights one can gain from a mathematical approach and the third is a new approach my group is taking that I was the catalyst, but not the prime mover for: use of evolutionary game theory in testing putative treatment strategies (in this case for metastatic prostate cancer). 

I will also include the links to some of the groups in which I work to give some more flavor of what we do.  Thanks for your interest and feel free to contact me with questions!


Jacob Scott

My groups: