Jeffrey Iliff

Neuroscientist Jeff Iliff illuminates a newly discovered, critical function of the brain during sleep, a natural cleansing system that keeps toxic proteins at bay.

“My dad is a mouse doctor. Someday he’ll work his way up to be a monkey doctor. Then a person doctor.” - Sam, Jeff’s son, age 5.


Neuroscientist Jeff Iliff 's research follows two main paths. The first is the exploration of how the brain’s support cells, called glia, contribute to maintaining the proper environment for neuronal function and how their failure in conditions like vascular dementia, stroke, and traumatic brain injury leads to neurodegeneration. The second seeks to define the basic cellular mechanisms by which brain blood flow is coordinated up and down the vascular tree. Now an Assistant Professor of Anesthesiology and Perioperative Medicine at Oregon Health & Science University, Jeff was a part of a University of Rochester Medical Center team that discovered a brain cleansing system, which they dubbed the “glymphatic system.” When not doing research, Jeff enjoys hiking, reading, and spending time with his family.


Q&A with Jeff
Jeff opens up about his talk and why it matters now.

Sleep Drives Metabolite Clearance from the Adult Brain
Xie L, et al. Science. 2013 Oct 18;342(6156):373-377.

A Paravascular Pathway Facilitates CSF Flow Through the Brain.
Iliff J, et al. Sci Transl Med. 2012 Aug 15;4(147)ra111.

Impairment of Paravascular Clearance Pathways in the Aging Brain.
Kress, B.T., et al. Annals of neurology. 2014 Sep 10; PubMed.