Daniel Kohane, Professor of Anesthesia at Harvard Medical School and a Senior Associate in Pediatric Critical Care at Boston Children’s Hospital, reveals some of the amazing work he’s doing with nanoparticle technology to transform the power, safety, and specificity of drugs.
“The ability to combine drug targeting and triggering technologies will allow greater drug efficacy while minimizing drug toxicity.”
— Daniel Kohane
Daniel Kohane is a leading drug delivery and biomaterials researcher who uses nanoparticle technology to transform the power, safety, and specificity of drugs. A doctor of both medicine and physiology, with clinical training in pediatric anesthesiology and critical care, he is a multidisciplinary problem solver whether directing his biomedical engineering lab or caring for gravely ill children in the hospital. Dan is a Professor of Anesthesia at Harvard Medical School and a Senior Associate in Pediatric Critical Care at Boston Children’s Hospital. When not inventing new vehicles for making medications safer and more effective and saving children’s lives, he tinkers in various other industries, including a recent project to enhance the smell of microwave pizza.”
INTRIGUED? HERE'S MORE...
Which superpower would you most like to have?
To travel faster than light or teleport so that I could go study life forms in distant solar systems.
If you could meet your 10-year-old self, what would you tell him?
I would tell him as little as possible other than very general encouragement, for fear of influencing his life decisions. After all, it is not obvious that I took the best path for him/me.
What do you do to lift your spirits?
Spend time with my family, read ancient texts, and practice karate…they do the trick.
Magic Medicine? The wonders of nanomedicine
Guest article by Daniel on the TEDMED Blog
Photothermally-targeted thermosensitive polymer-masked nanoparticles
Barhoumi A, Wang W, Zurakowski D, Langer R, Kohane DS. Nano Letters. 2014;14:3697-3701.
Near-infrared actuated devices for remotely controlled drug delivery
Timko BP, Arruebo M, Shankarappa SA, McAlvin JB, Okonkwo OS, Mizrahi B, Stefanescu CF, Gomez L, Zhu J, Zhu A, Santamaria J, Langer R, Kohane DS. Proc Natl Acad Sci USA. 2014;111:1349-54.
In vivo performance of a drug-eluting contact lens to treat glaucoma for a month
Ciolino JB, Stefanescu CF, Ross AE, Salvador B, Cortez P, Ford EM, Wymbs KA, Sprague SL, Mascoop DR, Rudina SS, Trauger SA, Cade F, Kohane DS. Biomaterials. 2014;35:432-9.
Photoswitchable nanoparticles for in vivo cancer chemotherapy
Tong R, Chiang HH, Kohane DS. Proc Natl Acad Sci USA. 2013;110:19048-53.
Prolonged nerve blockade delays the onset of neuropathic pain
Shankarappa SA, Tsui JH, Kim KN, Reznor G, Dohlman JC, Langer R, Kohane DS.
Proc Natl Acad Sci USA. 2012;109:17555-60.
Photoswitchable nanoparticles for triggered tissue penetration and drug delivery
Tong R, Hemmatti HD, Langer R, Kohane DS. J Amer Chemical Soc 2012; 134: 8848-55.
Nanoparticles targeting the infarcted heart
Dvir T, Bauer M, Schroeder A, Tsui J, Anderson DG, Langer R, Liao R, Kohane DS. Nano Letters 2011; 11: 4411-4.
Nanotechnological strategies for engineering complex tissues
Dvir T, Timko BP, Kohane DS, Langer R. Nature Nanotech. 2011;6:13-22.
Dvir T, Banghart MR, Timko BP, Langer R, Kohane DS. Nano Letters. 2010;10:250-4.
Remotely triggerable drug delivery systems
Timko BP, Dvir T, Kohane DS. Adv Mater. 2010;22;4925-43.
Prolonged duration local anesthesia with minimal toxicity
Epstein-Barash H, Shichor I, Kwon AH, Hall S, Lawlor MW, Langer R, Kohane DS. Proc Natl Acad Sci USA. 2009;106:7125-30.
A drug-eluting contact lens
Ciolino JB, Hoare TR, Iwata NG, Behlau I, Dohlman CH, Langer R, Kohane DS. Invest Ophthalmol Vis Sci. 2009;50:3346-42.