IN A NUTSHELLWhat if next generation sequencing could help us diagnose mysterious infectious illnesses?
ABOUT CHARLESInfectious disease physician and clinical microbiologist Charles Chiu is the director of the University of California, San Francisco (UCSF)-Abbott Viral Diagnostics and Discovery Center, a translational research laboratory engaged in the development and validation of next-generation sequencing assays, pathogen discovery, bioinformatics software design, nanopore sequencing, and characterization of emerging infections (such as Lyme disease, enterovirus D68, and Zika virus). Next-generation sequencing can dramatically reduce the time necessary for clinical diagnosis of infections from rare, novel, or unexpected pathogens − including viruses, bacteria, fungi, and parasites, and its emergence heralds a new era in infectious disease diagnostics. Charles has authored more than 60 peer-reviewed publications, holds over 15 patents and patent applications, and serves on the scientific advisory board for Therabio, Karius, and Rubicon Genomics.
LEARN MORECharles Chiu’s UCSF Profile
New Gene Discovery Could Lead to Earlier Lyme Test And Diagnosis
Stone J. Forbes. 2016.
New, Rapid Zika Test Has Been Working, UCSF Researcher Says
Sadiq S, Brooks J. KQED Science. 2016.
Ebola, Zika and More: Designing One Test to Catch Them All
Madhusoodanan J. UCSF News Center. 2016.
Utility of Metagenomic Next-Generation Sequencing for Characterization of HIV and Human Pegivirus Diversity
Chiu CY, Luk KC, Berg MG, Naccache SN, Kabre B, Federman S, et al. PLoS ONE. 2015;10(11):e0141723.
An ensemble strategy that significantly improves de novo assembly of microbial genomes from metagenomic next-generation sequencing data
Chiu CY, Deng X, Naccache SN, Ng T, Federman S, Li L, Delwart EL. Nucl. Acids Res. 2015;43(7):e46.
‘Polio-like’ strain of enterovirus D68 may be responsible for mystery paralysis, study says
Cha AE. The Washington Post. 2015.
A New Strain Of Enterovirus D68 May Be The Cause Of Recent Childhood Paralysis Cases
Almendrala A. Huffington Post. 2015.
Mysterious Childhood Paralysis Linked To A Cold Virus
Sneed A. Wired. 2015.
Enterovirus 68 May Be Linked to Paralysis in Children, Study Says
Saint Louis C. The New York Times. 2015.
Actionable Diagnosis of Neuroleptospirosis by Next-Generation Sequencing
Chiu CY, Wilson MR, Naccache SN, Samayoa E, Biagtan M, Bashir H, et al. N Engl J Med. 2014;370:2408-2417.
In a First, Test of DNA Finds Root of Illness
Zimmer C. The New York Times. 2014.
Faster DNA Sleuthing Saves Critically Ill Boy
Norris J. UCSF News Center. 2014.
Quick DNA Tests Crack Medical Mysteries Otherwise Missed
Harris R. NPR. 2014.
Boy’s Mysterious Infection Cured After DNA Sequencing
Fox M. NBC News. 2014.
Disease Detectives Catch Deadly African Virus Just As It Emerges.
Knox R. NPR. 2012.